Purity: | 99% | Mf: | C26H28Cl2N4O4 |
---|---|---|---|
Cas No.: | 65277-42-1 | Appearance: | White Powder |
Usage: | Pharmaceutical Intermediates | Shelf Life: | 24 Month |
Molecular Weight: | 531.431 | Test Method: | HPLC |
High Light: | API Ketoconazole Dusting Powder,Antifungal Ketoconazole Powder,99 Purity Mifepristone Powder |
Antifungal Agent Ketoconazole Powder CAS 65277-42-1 99% Ketoconazole
Prodcut name | Ketoconazole |
MOQ | 1kg |
CAS No. |
65277-42-1 |
Appearance | White powder |
Molecular Formula | C26H28Cl2N4O4 |
Molecular Weight | 531.431 |
Assay | 99% |
Application | Pharma grade |
The Introductction of Ketoconazole:
The Application & Function of Ketoconazole:
Pharmacology: ketoconazole belongs to azol-class antifungal drugs and has antifungal activity against various kinds of genus of deep fungal infections such as Candida, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp as well as Trichophyton. . It destroys the fungal cell membrane and changes its permeability, resulting in the leakage of important intracellular material. Ketoconazole can also inhibit the biosynthesis of fungal triglyceride and phospholipid biosynthesis, inhibit the activity of oxidase and peroxidase, causing accumulation of intracellular hydrog peroxid which further leads to cell submicroscopic structural degeneration and necrosis. For candida albicans, it can also suppress the transition process from spores to aggressive mycelium.
Toxicology: Long-term animal toxicity experiments have showed that ketoconazole can significantly increase the level of alkaline phosphatase and cause liver cell degeneration.
The COA of Ketoconazole:
Item | Specifications |
Appearance | White or almost white crystal powder |
Identification | Conforms |
Specific rotatory power | -1~+10 |
Solubility | Solution water 1:10 |
Clarity of solution | Should be clartiy |
Colour of solution | ≤No.5 orange-yellow |
Relation substance | ≤1.5% |
Loss on drying | ≤0.5% |
Burn Residue | ≤0.1% |
Heavy metals | ≤0.002% |
Loss on drying | ≤0.50% |
Content | ≥98.5% |
Microbiological Test |
Bacteria :≤300cpu Fungi: ≤100cpu |
Reference addition | 0.5 ~ 2.0% It can dissolve in propylene glycol at first |
Conclusion | The results conforms with Enterprise standards |